Rescue of the defective murine sarcoma virus genome by radiation-induced leukemia virus from C57BL mice.
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چکیده
منابع مشابه
Rescue of murine sarcoma virus from a sarcoma-positive leukemia-negative cell line: requirement for replicating leukemia virus.
The nature of murine sarcoma virus (MSV) "defectiveness" was investigated by employing an MSV-transformed mouse 3T3 cell line which releases noninfectious virus-like particles. Rescue kinetics of MSV, observed after murine leukemia virus (MuLV) superinfection of these "sarcoma-positive leukemia-negative (S + L -)" mouse 3T3 cells, consisted of a 9- to 12-hr eclipse period followed by simultaneo...
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Hartley and Rowel reported that the in vitro focus-forming effects of Moloney sarcoma virus (MSV)2 I depended on the presence in the same cells of two virus particles, a defective i\ISV particle and a fully infectious Moloney leukemia particle. Superinfection with additional Moloney leukemia virus potentiated focus formation by MSV, converting a "two-hit" dose response curve to a one-hit curve;...
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Non-virus-producing NIH/3T3 cells transformed by the murine sarcoma virus are agglutinated by conconavalin A to the same low level as normal NIH/3T3 cells. Infection with the murine leukemia virus greatly increases the agglutination of transformed cells but not that of normal cells. These data suggest that the morphological expression of cell transformation and the surface alterations associate...
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The development of in vitro (tissue culture) assay systems for murine leukemia (MuLV)l" 2 and sarcoma (MSV)3-7 viruses, the demonstration of the defectiveness of the MSV genome,3 and its rescue with various MuLV's7 have brought out certain remarkable similarities between these viruses and those of the avian leukosisRous sarcoma complex.3' 7, 8, "a Subsequent studies of the murine viruses, which...
متن کاملThymic nurse cells and radiation leukemia virus induced thymic lymphomas in C57BL mice.
The selective thymotropism of radiation leukemia virus is an interesting example of specific interaction between an oncogenic agent and the differentiation pathway of a well-defined cell lineage. Indeed, the inoculation of RadLV in C57BL/Ka mice leads to the development of thymic lymphomas [4]. Only a few immature thymocytes can act as target cells for productive infection by RadLV [I]. Infecti...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1967
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.58.5.1870